Patent application for Baclofen and acamprosate based therapy of neurological disorders including alcoholism


It is becoming evident that excitotoxicity is involved in the pathogenesis of multiple disorders of various etiology such as: spinal cord injury, stroke, traumatic brain injury, hearing loss, alcoholism and alcohol withdrawal, alcoholic neuropathy, or neuropathic pain as well as neurodegenerative diseases such as multiple sclerosis, Alzheimer’s disease, Amyotrophic Lateral Sclerosis, Parkinson’ s disease, and Huntington’s disease (19-21). The development of efficient treatment for these diseases remains major public health issues due to their incidence as well as lack of curative treatments.

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