Baclofen has now been licensed for Alcohol treatment

France is the first country to license baclofen for alcoholism treatment.  A recommendation for temporary use was issued on 14 March 2014 for a period of 3 years.   The trials of baclofen are scheduled to end in May 2014 and the results will then be compiled so that the RTU will, in all likelihood, result … Continue reading Baclofen has now been licensed for Alcohol treatment

Clinical Experience With Baclofen in the Management of Alcohol-dependent Patients With Psychiatric ComorbidityA Selected Case SeriesG.M. Dore, K. Lo, L. Juckes, S. Bezyan, N. LattDisclosuresAlcohol Alcohol. 2011;46(6):714-720. 1 commentPrintAbstract and IntroductionPatients and MethodsResultsDiscussionReferencesRelated LinksEfficacy of As-Needed Nalmefene in Alcohol-Dependent Patients With at Least a High Drinking Risk LevelWant Hospital Admitting Privileges? First Pass a Drug TestPsychiatric Treatment … Continue reading

Public statement of Prof. J. Borer, chief of internal medicine and cardiology at the University of the State of New York and international medical authorities about the discovery of Prof. O. Ameisen and its consequencesBy admin | November 28, 2011 January 23, 2010To whom it may concern :It is an honor for me to join the … Continue reading

There is a drug…

The following was written by Cassander, a lawyer and  contributor to the MWO forums: There is a drug (as in prescription drug) out there which seems to help a lot of people stop drinking. As in alcoholics. Its called baclofen. It is a safe, old drug which was discovered about 90 years ago as a treatment … Continue reading There is a drug…

Complete and prolonged suppression of symptoms and consequences of alcohol-dependence using high-dose baclofen. Case self study by Dr. Olivier Ameisen

Ameisen O. – Alcohol and Alcoholism. 2005 Mar-Apr;40(2):147-50. Epub 2004 Dec 13.AIMS: To test whether the dose-dependent motivation-suppressing effect of baclofen in animals could be transposed to humans, and suppress craving and sustain abstinence.METHODS: Neurologists safely use up to 300 mg/day (10 times the dosage currently used for alcohol dependence) of high-dose oral baclofen, to … Continue reading Complete and prolonged suppression of symptoms and consequences of alcohol-dependence using high-dose baclofen. Case self study by Dr. Olivier Ameisen

Adult Children of Alcoholics: Caught in an Infinite Loop? (Part 3 Exit Strategies)

Raising Healthy Children in an Alcoholic Home

???????????????????????????????????????????????????????????????????????????????????????????????????????? “Psychotherapy is a biological treatment, a brain therapy. It produces lasting, detectable physical changes in our brain, much as learning does.” –Dr.  Eric Kandel (Professor Columbia University and recipient, 2000 Nobel Prize in Physiology or Medicine)

This is the third in a series of articles about children of alcoholics who remain trapped in an alcoholic lifestyle as adults. Parts 1 and 2 explained that children who grow up in addicted families are likely to reproduce harmful features of their families of origin in their adult lives. When they involve themselves with destructive partners and activities that evoke feelings and patterns of behavior similar to those they witnessed and experienced as children, their lives become unmanageable. I examined the neurological and psychological underpinnings   of this painful “infinite loop” of chaos and disappointment that captures and captivates many adult children. In brief, neurological changes caused by traumatic experiences in childhood remodel the…

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Washington Post: How heroin changes the brain of an addict

Raising Healthy Children in an Alcoholic Home

See on Scoop.itAddictions and Mental Health

“It’s not just a willpower issue. The drug affects the part of the brain that responds to pleasurable things.”

http://goo.gl/R51UZ4

 

This is a good and highly readable discussion of neurological changes that occur with repeated use of psychoactive substances and  perpetuate addiction.  It highlights changes to the reward regions of the brain, explaining that the brain responds to drug-induced floods of dopamine by dampening its response to this neurotransmitter, and possibly to “all forms of pleasurable behavior”. Hence, addicts “seek larger and larger hits to achieve an ever-diminishing pleasure experience, and they have trouble feeling satisfaction from the things that healthy people enjoy.”

The article also explains that activities, people and places that become associated with the ingestion of psychoactive substances are eventually able to trigger, on their own, a cascade of dopamine into the nucleus accumbens, and thus provoke people…

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Kendall F. Person on Addiction: “A gale force wind blowing through the hole in your soul”

Raising Healthy Children in an Alcoholic Home

amywinehouse

“You never know when that addict in your life may need your hope, because they have none of their own, always leaving them inches away from giving up.”

This is a compelling post that describes the ravages of addiction from the inside out.  Mr. Person says it is not possible to describe hitting bottom to someone who has not experienced it, but perhaps he comes as close as anyone can with his eloquent account of his own experience as a “gale force wind…blowing through the hole in (my) soul.” 

For family members and professional helpers who may sometimes feel that nothing they do matters, Mr. Person also speaks  movingly of  the hope engendered by the  continued presence and persistence of those who loved him, and how this hope enabled him to move forward.

Find it here:  Our Featured Presentation: Addiction | Kendall F. Person, thepublicblogger.

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Baclofen’s role in stimulating Growth Hormone

Psychiatry Res. 1996 Feb 28;60(1):41-7.Growth hormone response to baclofen: a comparison of 10-mg and 20-mg doses in healthy men.Davis LL1, Trivedi M, Kramer GL, Rush AJ, Orsulak PJ, Akers L, Petty F.Author information AbstractGrowth hormone (GH) response and baclofen levels were measured in seven healthy adult men following a 10-mg and a 20-mg dose of … Continue reading Baclofen’s role in stimulating Growth Hormone

Failure of Autism drug, Arbablofen has a silver lining

Meeting CoverageFailed Autism Drug Study Has Silver LiningPublished: Nov 1, 2013By  John Gever , Deputy Managing Editor, MedPage Todaysave|AAAction PointsNote that this study was published as an abstract and presented at a conference. These data and conclusions should be considered to be preliminary until published in a peer-reviewed journal.AUSTIN, Texas -- The primary endpoint was … Continue reading Failure of Autism drug, Arbablofen has a silver lining

Arbaclofen – New Trial for Autism Treatment

The Epiphany autism blog reports. Wednesday, 27 November 2013Autism Clinical Trials, Arbaclofen (STX209), Curemark CM-AT and the Clever Chiropractor   In the world of clinical trials for drugs, judging success and failure can be highly subjective. They try to make it as logical as possible and the method works pretty well for assessing things that you … Continue reading Arbaclofen – New Trial for Autism Treatment

How Baclofen works in Autism

While benzodiazepines, like Lorezepam, and baclofen both work on GABA receptors, their mechanism of action is quite different. Benzos target the GABA "A" receptor, which is a chloride channel, while baclofen targets the GABA "B" receptor, which is a G-protein coupled receptor and regulates a different set of molecules from GABA "A". So it's possible … Continue reading How Baclofen works in Autism

End of arbaclofen study leaves children without medication

The decision to end trials of STX203 or arbaclofen for autism has left many families upset and distressed that their children will not be able to get a valuable medicine which was showing promise in treating autism.  Here is the response to the decision from one family:  Roche Backs Out on Seaside Therapeutics Drug Trial for … Continue reading End of arbaclofen study leaves children without medication

Autism and Baclofen

Autism and Baclofen Recent studies in autism have shown the effectiveness of STX209, a drug which is chemically similar to Baclofen in the treatment of autism.  It is 10 times more potent than Baclofen and target the same Gaba receptor.  Not available to the public until at least 2013 it give hope for the treatment … Continue reading Autism and Baclofen

Baclofen for Acute Alcohol Withdrawal

  Acute alcohol withdrawal symptoms Baclofen Can Ease Symptoms of Acute Alcohol Withdrawal Bob Roehr Authors and Disclosures Print This Email this ShareNovember 12, 2010 (Denver, Colorado) — A small study in Minnesota has replicated findings from Italy indicating that off-label use of the gamma-aminobutyric acid–derivative baclofen is effective in treating symptoms of alcohol withdrawal … Continue reading Baclofen for Acute Alcohol Withdrawal

Withdrawing from Baclofen – Risks of Rapid Withdrawal

Risks of withdrawal It is important to have a doctor supervise taking Baclofen.  There are significant side effects of taking too much Baclofen and withdrawing too quickly.  Dosage should be increased so as not to bring on side effects and when unwanted side effects are noticed, dosage should be reduced slightly to eliminate them. Too … Continue reading Withdrawing from Baclofen – Risks of Rapid Withdrawal

Baclofen and Opiates

Baclofen and Opiates - one man's story  My addiction testimony. My name is Pascal Gramme and I live in Belgium.I was addicted to opiates, benzodiazepines, and antidepressants.It all started one day in March 1993, a day I will never forget.This particular morning, I was at work and suffering from a severe toothache. The day seemed very inauspicious, … Continue reading Baclofen and Opiates